Dave,
People at your company are lucky to have someone like you to support them.
Imagine those people who do not have much experience with PTC products or those who migrate from a different CAD system. They will be at a total loss in terms of how to configure the interface. This stuff only makes sense if you've been around this system for a while. From my experience, most will use the out of the box configuration.
PTC needs to make the interface simple so that users could be most efficient out of the box. Right now, advanced users have to mess around with the interface to make the software easier to use. And in some cases, you can't even adress the usability issue. A successful interface is one that you don't have to tweak. The current interface is far from it.